The HN guidelines say "Please respond to the strongest plausible interpretation of what someone says". The way I understand it is that different people on the thread often have different ways of thinking about the topic, and we shouldn't dismiss something because it's not what "we" were talking about. In this case, it was obvious to you that the parent was talking about smoking tobacco, right? So you can either engage with it, or not, but there's no need to reject someone's comment for not adhering to what you decided is the topic.
Who's trying to avoid talking about tobacco? TFA is titled "Scientists solve 200-year-old puzzle of how tobacco plants make nicotine", and my sense is that the thread is very much about which of the effects of smoking are explained by nicotine, and which are better explained by other factors of smoking tobacco.