A few years back I was working at a software company that provided on-site sensor sensor networks to hospitals, pharmacies, etc. Our product required them to physically install a server on-site, but we were starting to get disrupted by cloud-based solutions. Essentially what we did was alert medical staff when blood, organs, etc. refrigeration temperatures went out of range. If the right people involved did not get notifications on time for these issues people will die. Its not hyperbole, you have to wait years for liver transplant. Their aren't just new livers available for everyone if a handful of them spoil.

With that being said, the problem here isn't that it took 75 minutes to find the root cause, but rather that the fix took hours to propagate through the us-east-1 data center network. Which is completely unacceptable for industries like healthcare where even small disruptions are a matter of life and death.