Hacker Newsnew | past | comments | ask | show | jobs | submitlogin

Phenylephrine doesn't work though. It never did. It was "pushed" as an alternative to pseudoephedrine which can be used to synthesize meth, but afaik every single study done on this shows that phenylephrine does absolutely nothing, it's a placebo drug. The faster it's phased out the better.


How it was approved in the first place should have been reviewed


It was approved back in the 70s after there being some studies that showed it was somewhat effective against congestion. I suspect it was no better than a placebo, but once it gets over the hurdle of being shown to be safe to use it probably didn't take much to get it approved. I don't think it was ever a popular product until the government starting making pseudoephedrine, which is highly effective, hard to buy.


Strictly speaking, phenylphrine works when it’s injected. It is approved and used every day for this indication in the service of general anesthesia.

However, the oral bioavailability is zero.

This is an example of using something off label that’s approved for something else. Sometimes it’s fine. And sometimes, it’s dumb.


That's cool to know - I had no idea! I assumed that it literally did nothing in every scenario.




Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: