This isn't tied to a single location/browser. You can mark sites from your javascript enabled phone, and read them on your desktop, or vice versa. If you use the web interface you can have it auto-hide any links you've already visited through the site. You can also get an RSS feed of your listings so that you don't NEED to use the web interface if that's your thing.

Edit: Thanks for the mention of the design, I'm far from a designer so I've been as worried about that aspect as any other.