More realistic numbers:

$300-500 roundtrip flight every week, $250/night in a hotel X 4 nights, $50 Ubers to/from the airport at both ends, plus meals and other incidentals.

That's closer to $85k/year.

> $250/night in a hotel X 4 nights

If you are staying in the city four nights a week you'll probably be better off getting a studio apartment, both in costs and comfort. SLU studios would be ~$2100/mo with utilities. If you assume $5000 for initial furnishing a studio will cost $30,000/yr instead of $50,000/yr for a hotel.

It'll also be faster to go between SEATAC and SLU on the Link Light Rail than an uber (unless you are traveling between 9pm-6am), which costs $2.25/ride compared to $50. So that reduces the costs by another $5000.

If you claim Washington state residency you can probably stop paying your current state income tax (Washington doesn't have one) which will save you thousands or tens of thousands a year.

After looking deeper into it my $15,000 estimate is way too low, but your $85,000 is much higher than reality for Seattle.

Where do you get $100/flight deals? Also you need to account for lodging during the week