Is this the same NAD+ that’s prescribed by longevity / hormone clinics?
Edit: after some googling, sounds like NAD+ (which you can get from real doctors) is the “building blocks” similar to how protein is the building blocks for muscle, while the experimental compound changes/enhances how the building blocks are used inside your cells.
So you might need some NAD+ precursor like NMN and this compound for it to work in humans because by the time you’re old it’s much harder for your body to make. Was the experiment done in older mice or younger ones that have NAD+ but artificial Alzheimer’s ?
NMN and NR are both good but NMN might not be available anymore as some company decided to repurpose it as a drug instead of supplement. Best combo nowadays looks to be liposomal NR with pterostilbene, a sirtuin activator. NR boosts NAD+ (the main electron transporter in mitochondria), pterostilbene activates sirtuin SIRT1 that regulates aging. B2/Riboflavin might be a good idea as well as it is a FADH donor, secondary electron transport carrier especially in nerves/brain. B1 to the mix as every single metabolic reaction needs it and it's depleted by consuming lots of carbs or drinking alcohol, a common western diet. Niacin is less effective in raising NAD+ but the flush can open up veins and flood hard to reach extremities of the body with blood so it's probably good from time to time. Slow B3 seems to be even worse for raising NAD+.
- you took niacin too often (best to do it once a few days as body adapts quickly)
- you have a gene mutation that prevents you from absorbing enough B3 (common in some schizophrenia cases that can be managed by huge doses of daily B3, like 4-10g)
it kinda sucks, but with the constraints it's at least understandable. they wanted an extremely lightweight language with a bytecode VM which could be ported to whatever MCUs in 2015, while also strictly limiting the functionality for battery usage reasons (and, uh, product segmentation/limiting third party access).
I just tested the mediocre enterprise nvme I have sitting on my desk (micron 7400 pro), it does over 30000 fsyncs per second (over a thunderbolt adapter to my laptop, even)
Another complexity here besides syncs per second is the size of the requests and duration of this test, since so many products will have faster cache/buffer layers which can be exhausted. The effect is similar whether this is a "non-volatile RAM" area on a traditional RAID controller, intermediate write zones in a complex SSD controller, or some logging/journaling layer on another volume storage abstraction like ZFS.
It is great as long as your actual workload fits, but misleading if a microbenchmark doesn't inform you of the knee in the curve where you exhaust the buffer and start observing the storage controller as it retires things from this buffer zone to the other long-term storage areas. There can also be far more variance in this state as it includes not just slower storage layers, but more bookkeeping or even garbage-collection functions.
Having a longer life gives you a greater total capacity to do and create meaningful things. But the meaning of any given fixed-time act is less if the lifespan is shorter.
Spending half your life writing a book makes that book more meaningful than spending a tenth of your life doing it. But you can only write two of the former versus ten of the latter.
Either way, this is a simple and dumb mathematical model, not a literal equation for calculating the actual value of a life's work.
if my body and mind were falling apart and all my friends/family went before me maybe I'd be ready... but I see that as a huge argument in favor of immortality since I want people I care about to be alive and healthy
> seems to work very well for a potentially lethal disease
not lethal for all age groups, we already knew it well before the vaccine was introduced. People may have short memories, the vaccine came almost a year after the disease was out, and we knew very well by then that it did not kill everyone, broadly.
> not lethal for all age groups, we already knew it well before the vaccine was introduced. People may have short memories, the vaccine came almost a year after the disease was out, and we knew very well by then that it did not kill everyone, broadly.
And the vaccine wasn't trialed or rolled out initially for all age groups. One major reason was because double-blind trials were done first.
This one was was 18-59: https://clinicaltrials.gov/study/NCT04582344 with two cohorts: "The first cohort will be healthcare workers in the high risk group (K-1) and the second cohort will be people at normal risk (K-2)"
If you look at case rates, hospitalization load, and death rates for summer/fall/winter 2020 pre-vaccine, and compare to the load on the system in summer-2021 and later when people were far more social and active, the economy was starting to recover, then the efficacy of the vaccine was pretty obvious in letting people get out of lockdown without killing hugely more people and overwhelming the healthcare system. And it was tested pre-rollout in double-blind fashion and rolled out in a phased way to the most needy groups first, with monitoring and study of those groups.
What, concretely, are you proposing should have been done differently?
Did you even follow the link provided? It leads directly to an informed consent page for the study, which was voluntary. You're probably thinking about what happened _after_ these studies found the vaccine to be safe and effective. If you're a doctor or a nurse, you work in a special environment, and if you are turning down a safe and effective vaccine, you are putting your patients at risk. It means that you are unqualified for your job, so yes, you should be fired.
In the US at least, most people are employed "at will" [1], which means that you can be fired for reasons far less egregious than actually putting your patients at risk. Most of the libertarian types here cheer firings for lots of reasons, but for some reason being fired for actually being a health risk is not one of those things. That just makes no sense.
Besides, homeopathy has been studied for ages with tons and tons of quality studies.
Did it get rid of all the homeopathic quackery?
They will always have an excuse. If all else fails it'll just be a vague generic "oh yeah, it's just something deeper your science can't measure yet" or something along those lines. The Queen was an amateur hand-waver in comparison.
Never mind it was never very likely to work in the first place, on account of defying basic logic on several levels: like cures like, the whole water memory business, the more you dilute the stronger it becomes – nothing about this makes any sense.
I miss the days when worry about the adverse effects of homeopathy was the top concern...
most of the critics of this particular vaccine are the ones that took it. either the people who got covid anyway or were injured by it.
it was incredibly destructive for trust in the medical establishment to oversell / mandate it and market aggressively as "safe and effective". while most vaccine risks are in the 10s per 100k or 1M, nearly everybody knows somebody else who had an adverse reaction to one of the covid shots.
nearly everybody observed that you still get and spread covid anyway. that is disconnected from the aggressive messaging from the CDC and the fear and shame campaign from the last US administration.
criticism of a specific vaccine or policy does not make someone an anti-vaxxer that moves goalposts. the establishment is responsible for the skepticism it engendered against itself by its hubris
I took it in 2020, and have taken booster shots. I got COVID... This year. I felt like shit for two weeks, was fatigured for a month, and had a lingering cough for two.
Nobody's promised them that they won't get COVID after taking it. What is promised is that on the whole, they'd be less likely to get sick, get milder symptoms if they do get sick, and be less likely to require hospitalization or a mortician if those milder symptoms are still serious.
It was and is safe and effective. You're doing exactly what I'm talking about - moving the goalposts.
If you think they need to be moved some more, I'll point out that the vaccine didn't come with a free pony, either, and that airbags and seatbelts kill ~50 people/year, and that you might still get ran over by a bus even if you look both ways before crossing the street.
Perhaps any statement in that context should be assumed to be oversimplified; but I don't think I can fault someone for taking words to mean what they literally say. The COVID vaccines look great so far on balance, but they absolutely were oversold to the public. We'll pay the price in public confidence for at least a generation.
Could you give the whole paragraph, and not just the last sentence in it?
Ah, heck, I'll do the work of pasting it in.
> But again, one last thing. I — we don’t talk enough to you about this, I don’t think. One last thing that’s really important is: We’re not in a position where we think that any virus — including the Delta virus, which is much more transmissible and more deadly in terms of non — unvaccinated people — the vi- — the various shots that people are getting now cover that. They’re — you’re okay. You’re not going to — you’re not going to get COVID if you have these vaccinations. -Biden
I'm not sure why out of all that Trump-lite-contradictory rambling (and the massive amounts of other words and ink spilled by both the 2020[1] and the 2021 administrations on this subject), that sentence is the singular, unqualified, pinky-swear blood-pact promise that you think the medical community made to the public regarding the vaccine.
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As for Walensky:
> Three days later, on April 1, a CDC spokesperson seemingly walked back the director’s comments, telling The New York Times “Dr. Walensky spoke broadly during this interview” adding that “It’s possible that some people who are fully vaccinated could get Covid-19. The evidence isn’t clear whether they can spread the virus to others. We are continuing to evaluate the evidence.”
If you're only going to listen to the first thing that's said on a subject, and ignore everything that follows, I don't think that sort of approach will serve you very well. For one thing, it'll probably mean that you'll think that people who correct themselves are idiots.
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[1] Which, if I may remind you, developed, recommended, and rolled out the vaccine and had nothing to do with Biden.
I'm not sure what the rest of the paragraph adds here? Nothing in that qualifies or contradicts the absolute that I quoted. Are you just saying that the statement was so generally inarticulate that any reasonable person should have ignored it completely? That was true here, but that's not great for public confidence either.
I'm aware that the scientific literature told a more nuanced and accurate story, but only a tiny fraction of the population have the skills and time to study that. I don't think you can fault people for trusting their elected leaders; and if you do, then who are you expecting them to trust next time?
> a CDC spokesperson seemingly walked back the director’s comments
So after widespread criticism by actual scientists, she didn't even correct herself in her own voice, instead sending an unnamed spokesperson to smooth it over without explicitly acknowledging error. I can't believe you don't see how the damage is done.
In a March 29 2021, MSNBC interview, Rochelle Walensky stated publicly that CDC data suggested "vaccinated people do not carry the virus" and "don't get sick". a knowingly false statement at the time and at best an inexcusable error from the head of that agency.
I also had covid this year, zero boosters, had a mild fever and sniffle for two days. not sure what you are demonstrating with this anecdote. or what goalposts you think I moved. the "milder symptom" stuff all came long after it was obvious that the covid shots were not doing what had been promised. that is what I would call moving the goalposts
“nearly everybody knows somebody else who had an adverse reaction to one of the covid shots.”
This is a straight up lie - because “adverse reaction” does not mean “I felt achy for a couple days and maybe had a little fever,” it’s actually a VERY specific term.
But you are trying to peddle falsehoods.
Most people know nobody who “had an adverse reaction to one of the covid shots”
respectfully it is not a lie, and more than a half a dozen people I know personally lost function of their hands, legs, were hospitalized with myocarditis, had local paralysis/palsy. I personally lost the use of my hand for two months and it took two more years to recover.
and when people like me say things like this, inevitably someone like you comes along to tell them they are dangerous for saying it out loud. In fact, the government was actively censoring people from being able to express this on social media.
there are studies about this compound from a decade ago, kinda doubt it's going to be a breakthrough at this point
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